The search for effective facial rejuvenation treatments is constantly evolving in Portugal and around the world. In recent years, PDRN (polynucleotides) have emerged as an advanced solution with proven results in skin regeneration and quality improvement.
ℹ️ But What Are Polynucleotides?
PDRN (polynucleotides) are DNA fragments obtained from natural sources, such as fish DNA (usually from trout or salmon), processed for medical and aesthetic use. These compounds are known for their ability to stimulate cellular regeneration and improve skin health.
They work directly on repairing the DNA of our skin cells, promoting deep regeneration and helping to combat the signs of aging.
📍 At Atelier do Sorriso in Almancil, in the heart of the Algarve, we recognize the importance of offering innovative and safe treatments that align with our patients’ expectations.
This article explains in detail what polynucleotides are, how they work, and why they are transforming aesthetic medicine in Portugal.
Benefits of PDRN in Facial Rejuvenation
PDRN (polynucleotides) play a key role in skin regeneration, being recognized as an effective and safe solution for facial rejuvenation.
This treatment combines cellular repair properties with biological stimuli that revitalize and strengthen the skin’s structures, providing natural and long-lasting results. Here are some of the main benefits and mechanisms of action:
✔️ DNA Repair and Cellular Regeneration
Polynucleotides act directly on the DNA of skin cells, repairing damage and accelerating cell renewal. This process replaces aged or damaged cells with healthier ones, promoting refreshed and more vibrant-looking skin.
✔️ Stimulation of Collagen and Elastin Production
This treatment activates fibroblasts, the cells responsible for collagen and elastin synthesis. As a result, the skin regains its firmness and elasticity, reducing wrinkles and fine lines.
✔️ Deep and Long-Lasting Hydration
PDRN helps retain moisture in the deep layers of the skin, improving long-term hydration. This effect gives the skin a smoother, more radiant, and revitalized appearance.
✔️ Anti-Inflammatory and Healing Properties
Thanks to their ability to reduce inflammation and promote healing, polynucleotides are suitable for sensitive skin or conditions like rosacea, irritations, or acne scars. This soothing effect also accelerates skin recovery after other aesthetic procedures.
✔️ Smoother Texture and Even Skin Tone
Regular use of PDRN visibly improves skin texture, making it smoother and more even. Additionally, it reduces spots and other signs of damage caused by the sun or aging.
✔️ Natural and Progressive Results
Unlike treatments that may alter facial expressions, PDRN offers subtle and continuous improvement, respecting the patient’s natural appearance. With regular sessions, the results become more noticeable and long-lasting.
✔️ Quick Recovery and Safety
Since it is minimally invasive, polynucleotide treatment requires little recovery time, allowing patients to resume their usual activities on the same day.
This set of benefits makes PDRN an excellent choice for those looking to address signs of aging, improve skin texture, and restore vitality. At Atelier do Sorriso, we ensure that each treatment is tailored to the individual needs of our patients, providing optimized results and a safe experience.
Who Is PDRN Treatment For?
PDRN (polynucleotides) are recommended for individuals looking to improve the appearance and health of their skin naturally and safely. This treatment is versatile and suitable for different ages, skin conditions, and aesthetic goals. Key indications include:
- Signs of Aging: Ideal for those who want to reduce fine wrinkles, expression lines, and skin laxity. Polynucleotides help restore skin elasticity, giving it a more youthful appearance.
- Dehydrated or Dull Skin: Patients with dry, lackluster skin or signs of fatigue find PDRN a solution for deep hydration and revitalization.
- Scars and Skin Marks: This treatment is effective in addressing acne scars or marks caused by injuries or previous procedures.
- Post-Aesthetic Procedure Recovery: After treatments like chemical peels, laser, or microneedling, polynucleotides accelerate recovery and minimize inflammation.
- Sensitive or Reactive Skin: Thanks to their anti-inflammatory properties, PDRN are suitable for patients with rosacea or skin prone to external aggressions.
- Men and Women: Suitable for anyone looking to improve skin quality without resorting to invasive methods.
⚙️ How Is PDRN Treatment Performed?
PDRN (polynucleotides) treatment is a minimally invasive procedure performed in a clinical setting under the supervision of qualified professionals. It is designed to ensure safety, comfort, and effective results.
Steps of the PDRN Procedure:
- Initial Consultation and Personalized Planning: Before starting the treatment, the doctor assesses the patient’s skin condition and defines an individualized plan. At this stage, priority areas are identified, and all questions about the procedure are clarified.
- Skin Preparation: The skin is cleansed, and a topical anesthetic is usually applied to reduce any discomfort during the application. This step ensures a more comfortable experience.
- Application of Polynucleotides: PDRN are injected directly into the dermis through microinjections. These are evenly distributed across the treatment areas, allowing polynucleotides to act effectively on the entire surface.
- Immediate Post-Treatment Care: After the procedure, a soothing cream may be applied to minimize redness or irritation. Although patients can resume daily activities on the same day, it is recommended to avoid intense sun exposure and makeup for the first 24 hours.
⏳ Duration of the Consultation and Number of PDRN Sessions:
Each session lasts about 30 to 60 minutes, depending on the size of the treatment area. For long-lasting results, 3 to 4 sessions are recommended, spaced 2 to 4 weeks apart. The maintenance plan is adjusted according to the patient’s individual response.
Safety and Tolerance:
The procedure is safe, with few risks and quick recovery. However, it is essential to undergo treatment at specialized clinics, such as Atelier do Sorriso, to ensure the highest quality standards.
Schedule a Polynucleotide Consultation in the Algarve
Discover how polynucleotides can transform your skin, restoring the confidence and radiance you deserve.
Call (+351) 915 550 999 ℹ️ or use the form below to schedule your consultation at our Atelier do Sorriso Clinic in Almancil, Faro, in the heart of the Algarve.
⁉️ FAQ: Frequently Asked Questions About PDRN (Polynucleotide) Treatment
What is PDRN? What are Polynucleotides?
PDRN (polynucleotides) are DNA fragments extracted from natural sources, such as salmon, used to stimulate cellular regeneration and promote skin rejuvenation. This treatment improves hydration, reduces wrinkles and fine lines, and increases skin firmness safely and effectively.
How Does Polynucleotide Treatment Work for Facial Rejuvenation?
PDRN treatment is performed through microinjections applied to the skin. These injections stimulate cellular DNA repair, increasing collagen and elastin production, deep hydration, and improving skin texture.
Can I Undergo Polynucleotide Treatment in the Summer?
Yes, the treatment can be done at any time of the year. However, it’s important to avoid direct sun exposure in the first few days after the session and to use sunscreen to protect the skin.
What Are the Side Effects of PDRN Treatment?
Side effects are mild and temporary. They may include redness, slight swelling, or small bruises in the treated area, which disappear within a few days. Following post-treatment recommendations further reduces these risks.
Who Can Undergo PDRN Treatment?
This treatment is suitable for individuals who want to improve signs of aging, deeply hydrate their skin, treat scars (such as acne scars), or accelerate recovery after other aesthetic procedures. It’s also suitable for those with sensitive or redness-prone skin.
How Many PDRN Sessions Are Needed to See Results?
The number of sessions varies according to each patient’s needs. Typically, 3 to 4 sessions are recommended, spaced 2 to 4 weeks apart, to achieve long-lasting results.
How Long Does Each PDRN Treatment Session Last?
Each session lasts between 30 to 60 minutes, depending on the treatment area. It’s a quick procedure, ideal for those seeking an effective solution without disrupting their daily routine.
Are the Results of Polynucleotide Treatment Immediate?
While some improvements may be noticeable right after the first session, the results become more evident over the course of the treatment, with progressive improvements up to several weeks after the last application.
Does PDRN Treatment Hurt?
The procedure is virtually painless as a numbing cream is applied before the microinjections. The sensation may cause slight discomfort, but most patients find the treatment very tolerable.
Is Polynucleotide Treatment Safe?
Yes, the treatment is safe when performed by qualified professionals in certified clinics. The PDRN used at Atelier do Sorriso is of high quality and approved by regulatory bodies, ensuring safety and efficacy.
Why Choose PDRN (Polynucleotide) Treatment at Atelier do Sorriso?

At Atelier do Sorriso, we combine cutting-edge technology with personalized care, ensuring the best experience for those seeking advanced facial rejuvenation treatments.
Our goal is to exceed expectations, providing natural and long-lasting results while ensuring the comfort and safety of our patients.
1. Personalized Assessment for Each Patient
Every skin is unique, which is why we start the process with a detailed evaluation to understand the patient’s needs and goals. This way, we can personalize the PDRN (polynucleotide) treatment to achieve the best possible results.
2. Team of Specialized Professionals
Our team consists of experienced specialists in aesthetic dental medicine and facial harmonization, ensuring that each treatment is performed with precision and care. Additionally, we stay updated with the latest techniques and advancements in the field of polynucleotides.
3. Use of Certified Products and Technologies
We only use certified, high-quality products approved by regulatory bodies, ensuring the effectiveness and safety of our treatments. Our modern infrastructure is equipped to provide comfort and confidence at every stage of the procedure.
4. Natural and Progressive Results
At Atelier do Sorriso, we value natural beauty. PDRN treatment offers subtle and progressive improvements that respect each patient’s unique expression, without exaggeration or artificial results.
5. Welcoming Environment and Exceptional Professionalism
From the first contact, our commitment is to ensure that patients feel welcomed and well-informed. Our approach combines cordiality and professionalism, ensuring that each visit is comfortable and satisfying.
6. Prime Location in the Heart of the Algarve
We are located in one of the most prestigious regions of Portugal, providing easy access for both local and international patients seeking excellence in aesthetic dental medicine and facial rejuvenation.
Choosing Atelier do Sorriso means trusting a clinic that prioritizes quality, safety, and patient well-being. If you want to rejuvenate your skin and boost your self-esteem, our PDRN (polynucleotide) treatment is the ideal choice.