PDRN (polynucleotides): skin regeneration with natural results
The search for effective facial rejuvenation treatments is constantly evolving in Portugal and around the world. In recent years, PDRN (polynucleotides) have emerged as an advanced solution with proven results in skin regeneration and quality improvement.
But What Are Polynucleotides?
PDRN (polynucleotides) are DNA fragments obtained from natural sources, such as fish DNA (usually from trout or salmon), processed for medical and aesthetic use. These compounds are known for their ability to stimulate cellular regeneration and improve skin health.
They work directly on repairing the DNA of our skin cells, promoting deep regeneration and helping to combat the signs of aging.
📍 At Atelier do Sorriso in Almancil, in the heart of the Algarve, we recognize the importance of offering innovative and safe treatments that align with our patients’ expectations.
This article explains in detail what polynucleotides are, how they work, and why they are transforming aesthetic medicine in Portugal.
Benefits of PDRN in Facial Rejuvenation
PDRN (polynucleotides) play a key role in skin regeneration, being recognized as an effective and safe solution for facial rejuvenation.
This treatment combines cellular repair properties with biological stimuli that revitalize and strengthen the skin’s structures, providing natural and long-lasting results. Here are some of the main benefits and mechanisms of action:
DNA Repair and Cellular Regeneration
Polynucleotides act directly on the DNA of skin cells, repairing damage and accelerating cell renewal. This process replaces aged or damaged cells with healthier ones, promoting refreshed and more vibrant-looking skin.
Stimulation of Collagen and Elastin Production
This treatment activates fibroblasts, the cells responsible for collagen and elastin synthesis. As a result, the skin regains its firmness and elasticity, reducing wrinkles and fine lines.
Deep and Long-Lasting Hydration
PDRN helps retain moisture in the deep layers of the skin, improving long-term hydration. This effect gives the skin a smoother, more radiant, and revitalized appearance.
Anti-Inflammatory and Healing Properties
Thanks to their ability to reduce inflammation and promote healing, polynucleotides are suitable for sensitive skin or conditions like rosacea, irritations, or acne scars. This soothing effect also accelerates skin recovery after other aesthetic procedures.
Smoother Texture and Even Skin Tone
Regular use of PDRN visibly improves skin texture, making it smoother and more even. Additionally, it reduces spots and other signs of damage caused by the sun or aging.
Natural and Progressive Results
Unlike treatments that may alter facial expressions, PDRN offers subtle and continuous improvement, respecting the patient’s natural appearance. With regular sessions, the results become more noticeable and long-lasting.
Quick Recovery and Safety
Since it is minimally invasive, polynucleotide treatment requires little recovery time, allowing patients to resume their usual activities on the same day.
This set of benefits makes PDRN an excellent choice for those looking to address signs of aging, improve skin texture, and restore vitality. At Atelier do Sorriso, we ensure that each treatment is tailored to the individual needs of our patients, providing optimized results and a safe experience.
Want to know if this treatment is right for you? Book an assessment.
Who Is PDRN Treatment For?
PDRN (polynucleotides) are recommended for individuals looking to improve the appearance and health of their skin naturally and safely. This treatment is versatile and suitable for different ages, skin conditions, and aesthetic goals. Key indications include:
Signs of Aging
Ideal for those who want to reduce fine wrinkles, expression lines, and skin laxity. Polynucleotides help restore skin elasticity, giving it a more youthful appearance.
Dehydrated or Dull Skin
Patients with dry, lackluster skin or signs of fatigue find PDRN a solution for deep hydration and revitalization.
Scars and Skin Marks
This treatment is effective in addressing acne scars or marks caused by injuries or previous procedures.
Post-Aesthetic Procedure Recovery
After treatments like chemical peels, laser, or microneedling, polynucleotides accelerate recovery and minimize inflammation.
Sensitive or Reactive Skin
Thanks to their anti-inflammatory properties, PDRN are suitable for patients with rosacea or skin prone to external aggressions.
Men and Women
Suitable for anyone looking to improve skin quality without resorting to invasive methods.
How Is PDRN Treatment Performed?
PDRN (polynucleotides) treatment is a minimally invasive procedure performed in a clinical setting under the supervision of qualified professionals. It is designed to ensure safety, comfort, and effective results.
Steps of the PDRN Procedure:
Initial Consultation and Personalized Planning
Before starting the treatment, the doctor assesses the patient’s skin condition and defines an individualized plan. At this stage, priority areas are identified, and all questions about the procedure are clarified.
Skin Preparation
The skin is cleansed, and a topical anesthetic is usually applied to reduce any discomfort during the application. This step ensures a more comfortable experience.
Application of Polynucleotides
PDRN are injected directly into the dermis through microinjections. These are evenly distributed across the treatment areas, allowing polynucleotides to act effectively on the entire surface.
Immediate Post-Treatment Care
After the procedure, a soothing cream may be applied to minimize redness or irritation. Although patients can resume daily activities on the same day, it is recommended to avoid intense sun exposure and makeup for the first 24 hours.
Duration of the Consultation and Number of PDRN Sessions:
Each session lasts about 30 to 60 minutes, depending on the size of the treatment area. For long-lasting results, 3 to 4 sessions are recommended, spaced 2 to 4 weeks apart. The maintenance plan is adjusted according to the patient’s individual response.
Safety and Tolerance:
The procedure is safe, with few risks and quick recovery. However, it is essential to undergo treatment at specialized clinics, such as Atelier do Sorriso, to ensure the highest quality standards.
FAQ: Frequently Asked Questions About PDRN (Polynucleotide) Treatment
What is PDRN? What are Polynucleotides?
PDRN (polynucleotides) are DNA fragments extracted from natural sources, such as salmon, used to stimulate cellular regeneration and promote skin rejuvenation. This treatment improves hydration, reduces wrinkles and fine lines, and increases skin firmness safely and effectively.
How Does Polynucleotide Treatment Work for Facial Rejuvenation?
PDRN treatment is performed through microinjections applied to the skin. These injections stimulate cellular DNA repair, increasing collagen and elastin production, deep hydration, and improving skin texture.
Can I Undergo Polynucleotide Treatment in the Summer?
Yes, the treatment can be done at any time of the year. However, it’s important to avoid direct sun exposure in the first few days after the session and to use sunscreen to protect the skin.
What Are the Side Effects of PDRN Treatment?
Side effects are mild and temporary. They may include redness, slight swelling, or small bruises in the treated area, which disappear within a few days. Following post-treatment recommendations further reduces these risks.
Who Can Undergo PDRN Treatment?
This treatment is suitable for individuals who want to improve signs of aging, deeply hydrate their skin, treat scars (such as acne scars), or accelerate recovery after other aesthetic procedures. It’s also suitable for those with sensitive or redness-prone skin.
How Many PDRN Sessions Are Needed to See Results?
The number of sessions varies according to each patient’s needs. Typically, 3 to 4 sessions are recommended, spaced 2 to 4 weeks apart, to achieve long-lasting results.
How Long Does Each PDRN Treatment Session Last?
Each session lasts between 30 to 60 minutes, depending on the treatment area. It’s a quick procedure, ideal for those seeking an effective solution without disrupting their daily routine.
Are the Results of Polynucleotide Treatment Immediate?
While some improvements may be noticeable right after the first session, the results become more evident over the course of the treatment, with progressive improvements up to several weeks after the last application.
Does PDRN Treatment Hurt?
The procedure is virtually painless as a numbing cream is applied before the microinjections. The sensation may cause slight discomfort, but most patients find the treatment very tolerable.
Is Polynucleotide Treatment Safe?
Yes, the treatment is safe when performed by qualified professionals in certified clinics. The PDRN used at Atelier do Sorriso is of high quality and approved by regulatory bodies, ensuring safety and efficacy.
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Atelier do Sorriso:
PDRN Treatment in the Algarve
Polynucleotides (PDRN) stimulate cell repair, collagen and deep skin hydration. At Atelier do Sorriso every treatment starts with an individual assessment and uses certified products.
Cell Regeneration
Helps repair and renew skin cells.
Collagen and Elastin
Stimulates firmness and elasticity.
Deep Hydration
Improves hydration in a lasting way.
Anti-inflammatory Action
Has soothing and healing properties.
Certified Products
We use certified products and technologies.
Quick Recovery
A well-tolerated procedure with a quick return to your routine.
Photos of our clinic in Almancil, Algarve, where we perform PDRN treatments:
5-star rated on Google
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Sile Harty28/10/2026Trustindex verifica se a fonte original da avaliação é Google.
I have been attending the clinic since 2024. Very friendly, professional and English speaking staff. I would highly recommend.Publicado em Google
Arthur Williams26/10/2026Trustindex verifica se a fonte original da avaliação é Google.
Excellent service Speak many languages I am very happy with service and high recommend this clinic And Celine is excellent on receptionPublicado em Google
Emmanuelle Guerreiro Guerreiro26/10/2026Trustindex verifica se a fonte original da avaliação é Google.
Excelente atendimento e excelente tratamento.Publicado em Google
Jan-Gerd van Senden25/10/2026Trustindex verifica se a fonte original da avaliação é Google.
Prettige tandartsPublicado em Google
Beatriz Santos23/10/2026Trustindex verifica se a fonte original da avaliação é Google.
Óptimo atendimento. Muitos profissionais. Procedimentos muito cuidadosos. Nada de dor associada! Agradeço em especial à Dra. Adriana e Dra. Marília 😊Publicado em Google
franck samouillan22/10/2026Trustindex verifica se a fonte original da avaliação é Google.
L’atelier do Sorriso ont une équipe médicale très professionnelle est compétente ainsi que l’équipe d’accueil très réactive









